Prescription skincare for skin you want to be in.
Azelaic Acid / Niacinamide / Tretinoin
$44.50/month
Billed as $89 every 2 months
Results
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.
About This Formula
Fine lines, uneven tone, and loss of firmness aren’t inevitable. They’re the result of slowing cell turnover and collagen production. Anti-Aging Care by DoctorDerm uses a prescription-strength combination of Tretinoin, Azelaic Acid, and Niacinamide to address the biology behind aging skin, not just the surface appearance.
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.
Anti-Aging Care contains Azelaic Acid, Niacinamide, and Tretinoin, three prescription-grade actives compounded into a single formula by a licensed pharmacy based on your provider’s prescription.
Apply a small amount to clean, dry skin as directed. Your provider will include specific application instructions with your prescription.
Complete a short skin assessment and upload a few photos. A licensed provider personally reviews your case and builds your treatment plan. If prescribed, your formula ships straight to your door.
Some patients begin to notice smoother texture and reduced fine lines within 6 to 12 weeks, though results vary. Continued improvement typically develops over several months with consistent use.
Clinically-Studied Ingredients
The Formula
Three prescription-grade actives. Working together to address aging at the source.
Azelaic Acid
C₉H₁₆O₄ · Dicarboxylic Acid
Azelaic Acid is a naturally occurring dicarboxylic acid with multiple mechanisms that make it valuable in anti-aging treatment. It inhibits tyrosinase, helping reduce melanin overproduction and may help fade the appearance of hyperpigmentation, age spots, and post-inflammatory discoloration. It also exerts anti-inflammatory effects that help calm irritation associated with retinoid use, making it an excellent pairing with Tretinoin. As a keratolytic, it gently promotes cell turnover to help improve surface texture and pore clarity. It is well tolerated across most skin types, including sensitive and rosacea-prone skin.
Niacinamide
C₆H₆N₂O · Vitamin B3
Niacinamide is a water-soluble form of Vitamin B3 that works across multiple pathways to support aging skin. It inhibits the transfer of melanosomes to keratinocytes, helping reduce the appearance of discoloration and age spots over time. It helps strengthen the skin’s lipid barrier by supporting ceramide production, which may help reduce transepidermal water loss and support resilience against environmental stressors. Niacinamide also helps regulate sebum and supports maintaining an even, refined skin surface, making it an ideal supportive ingredient alongside Tretinoin and Azelaic Acid.
Tretinoin
C₂₀H₂₈O₂ · Retinoid
Tretinoin is the gold standard prescription retinoid for anti-aging. It binds to retinoic acid receptors in skin cells, significantly accelerating the natural cell turnover cycle and supporting collagen synthesis. This may help reduce the appearance of fine lines, support improved skin firmness, and help create a more refined surface texture over time. Tretinoin may also help fade hyperpigmentation, reduce the appearance of pores, and help improve overall skin tone with consistent use. Because it increases cellular activity, some patients experience initial sensitivity or a brief purging phase in the first few weeks before seeing improvement.
This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.
Benefits
Supports smoother-looking skin over time
Prescription-strength Tretinoin helps support collagen production and cell turnover, which helps reduce the appearance of fine lines with consistent use.
Designed to support a more refreshed appearance
May help support the appearance of firmer, more refined skin at the cellular level with consistent use.
Designed to help with skin texture and surface quality
May help reduce the appearance of rough patches and uneven tone for a smoother-looking surface with consistent use over time.
Designed to help with uneven tone and dullness
Azelaic Acid may help reduce the appearance of dullness and address the appearance of hyperpigmentation, supporting a more even complexion over time.
Designed to support the skin barrier
Niacinamide is formulated to help support the skin’s lipid barrier, which may help reduce sensitivity and water loss over time.
How It Works
From your first question to your best skin. Here's how DoctorDerm works.
Take a quick skin assessment. Upload a few photos. No appointments, no waiting rooms.
A provider personally reviews your results and builds your treatment plan. Made for your skin, no one else's.
Your prescription treatment ships to your door every 60 days.
Adjust, check in, and get ongoing support whenever you need it.
The Difference
See how DoctorDerm stacks up against the alternatives.
| DoctorDerm | Other Online Clinics | In-Office Care | |
|---|---|---|---|
| Prescription-grade formula | |||
| Real provider reviews your case | |||
| Personalized to your skin | Partial | ||
| Ongoing provider support | |||
| No waiting room | |||
| Ships to your door |
This comparison is based on publicly available information as of 2026. We encourage you to do your own research. We're just pretty confident you'll end up here anyway.
The only place you get real provider care, real prescriptions, and real ongoing support, without ever leaving home.
Start My AssessmentReviews
”I have been using Anti-Aging Care for a few months and am seeing a big improvement! I am seeing a reduction in the appearance of wrinkles! Wish I had known about this a lot sooner.”
Verified Customer
“This prescription-strength product works for me while others I tried did not.”
Verified Customer
Rx-Grade
Prescription Formula
1,000+
Patients Treated
Licensed
Providers Only
Individual results may vary. Testimonials reflect personal experiences and do not guarantee outcomes.
FAQ
Results vary from person to person. Some patients begin to notice changes in skin texture and tone within a few months, while others see more gradual improvement over time. Consistent, long-term use is the most important factor.
Many people with sensitive skin can use this treatment. Your provider will review your skin concerns to determine appropriate concentrations, and may recommend easing in gradually to minimize irritation.
Yes. All DoctorDerm formulas are prescription-grade and require a provider consultation. Your assessment is the first step.
Tretinoin is not recommended during pregnancy. If you are pregnant or planning to become pregnant, please inform your provider during your assessment.
Tretinoin has clinical evidence supporting its role in helping reduce the appearance of fine-to-moderate lines and supporting improved overall skin texture. Very deep wrinkles may benefit from additional in-office procedures, which your provider can discuss with you.
Your provider will advise on what to use alongside your formula. Generally, a gentle cleanser, moisturizer, and daily SPF are recommended. Avoid combining with other strong actives unless your provider advises otherwise.
Tretinoin is prescription-strength retinoic acid, significantly more potent than over-the-counter retinol. Retinol must be converted by the skin before it can work; Tretinoin is already in its active form and works more directly and effectively.
DoctorDerm treatments combine ingredients into customized formulas that you typically wouldn’t receive as a single prescription in a traditional dermatology office. Our treatments are prepared and delivered directly to your door, giving you a complete skincare experience without the wait times or in-office visits.
$44.50/month. Billed as $89 every 2 months
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.