Calm skin starts with the right prescription.
Ivermectin / Niacinamide / Oxymetazoline HCl
$44.50/month
Billed as $89 every 2 months
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.
About This Formula
Most skincare products aren’t designed for rosacea. They treat the surface while ignoring what’s driving the flares underneath. Rosacea Care by DoctorDerm targets the actual causes: Demodex mites, chronic inflammation, and vascular instability, addressed with a prescription formula that addresses each layer of the problem.
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.
Rosacea Care contains Ivermectin, Niacinamide, and Oxymetazoline HCl: three prescription-grade actives compounded into a single formula by a licensed pharmacy based on your provider’s prescription.
Apply a small amount to clean, dry skin as directed. Your provider will include specific application instructions with your prescription.
Complete a short skin assessment and upload a few photos. A licensed provider personally reviews your case and builds your treatment plan. If prescribed, your formula ships straight to your door.
Many patients may begin to notice improvement in redness and irritation with consistent use. Individual results vary. of consistent use, though individual results vary.
Clinically-Studied Ingredients
The Formula
Three prescription-grade actives. Each one targeting a different layer of rosacea.
Ivermectin
C₄₈H₇₄O₁₄ · Antiparasitic
Ivermectin is a topical antiparasitic and anti-inflammatory agent that targets Demodex mites, microscopic parasites that colonize hair follicles and contribute to rosacea flares. By reducing Demodex density, Ivermectin may help interrupt the inflammatory cascade these mites trigger, supporting a reduction in the papules and pustules associated with papulopustular rosacea. It also may exert direct anti-inflammatory effects independent of its antiparasitic action, further supporting calming of the chronic low-grade inflammation characteristic of rosacea. Clinical studies have examined Ivermectin’s effects compared to metronidazole in reducing inflammatory lesions over a 12-week period. Most patients may begin to notice meaningful improvement with consistent use. Individual results vary.
Niacinamide
C₆H₆N₂O · Vitamin B3
Niacinamide is a water-soluble form of Vitamin B3 that supports rosacea-prone skin. It may support the skin’s compromised lipid barrier by stimulating ceramide production, which may help reduce the transepidermal water loss that makes rosacea skin hypersensitive to environmental triggers. As a potent anti-inflammatory, it may help calm the chronic redness, irritation, and sensitivity that define rosacea. It also helps support more even skin tone and may help reduce the appearance of post-inflammatory discoloration over time. Niacinamide is designed to work as a support ingredient alongside both Ivermectin and Oxymetazoline HCl, working across multiple layers of the rosacea picture.
Oxymetazoline HCl
C₁₆H₂₄N₂O · Alpha Agonist
Oxymetazoline HCl is a selective alpha-1A adrenoceptor agonist that works by constricting the superficial blood vessels responsible for persistent facial redness. When applied topically, it may help reduce the appearance of erythema within hours of application. A direct, mechanical action distinct from anti-inflammatory approaches. Oxymetazoline is the active ingredient in prescription Rhofade, an FDA-approved rosacea treatment. When combined with Ivermectin and Niacinamide in the DoctorDerm formula, it helps address rosacea across multiple pathways, supporting improvements in both the cause and the visible appearance of redness.
This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.
Benefits
Helps reduce visible redness
Oxymetazoline HCl targets the superficial blood vessels responsible for persistent facial redness, helping to reduce the appearance of redness within hours of application.
Targets rosacea triggers
Ivermectin may help reduce Demodex mite density, supporting reduced inflammatory cascade effects associated with papules and pustules characteristic of rosacea.
Calms chronic inflammation
Niacinamide works as a potent anti-inflammatory, calming the sensitivity and irritation that define rosacea-prone skin.
Strengthens the skin barrier
Supports ceramide production to reduce transepidermal water loss and hypersensitivity to environmental triggers like heat, wind, and sun.
Fully online, fully personal
A licensed provider reviews your case and prescribes a formula tailored to your skin. No in-office visit required.
How It Works
From your first question to your best skin. Here's how DoctorDerm works.
Take a quick skin assessment. Upload a few photos. No appointments, no waiting rooms.
A provider personally reviews your results and builds your treatment plan. Made for your skin, no one else's.
Your prescription treatment ships to your door every 60 days.
Adjust, check in, and get ongoing support whenever you need it.
The Difference
See how DoctorDerm stacks up against the alternatives.
| DoctorDerm | Other Online Clinics | In-Office Care | |
|---|---|---|---|
| Prescription-grade formula | |||
| Real provider reviews your case | |||
| Personalized to your skin | Partial | ||
| Ongoing provider support | |||
| No waiting room | |||
| Ships to your door |
This comparison is based on publicly available information as of 2026. We encourage you to do your own research. We're just pretty confident you'll end up here anyway.
The only place you get real provider care, real prescriptions, and real ongoing support, without ever leaving home.
Start My AssessmentReviews
“I have been using Rosacea Care for months and I have seen such an improvement in my skin! Finally my rosacea is under control. This was so easy, wish I had it before, definitely will keep buying.”
Verified Customer
“DoctorDerm providers combine real clinical expertise with a genuine interest in patient well-being. Finally getting the care I deserve.”
Verified Customer
Rx-Grade
Prescription Formula
1,000+
Patients Treated
Licensed
Providers Only
Individual results may vary. Testimonials reflect personal experiences and do not guarantee outcomes.
FAQ
Many patients may begin to notice improvement in redness and irritation with consistent use. Individual results vary. of consistent use, though individual results vary.
Yes. The ingredients in this formula are specifically chosen for their tolerability in rosacea-prone, reactive skin. Your provider will review your history to confirm it’s appropriate for you.
Yes. All DoctorDerm formulas are prescription-grade and require a provider consultation. Your assessment is the first step.
Common triggers include sun exposure, heat, alcohol, spicy foods, and stress. This formula helps calm the underlying inflammation and reduce the visibility of redness, though avoiding personal triggers is also an important part of rosacea care.
Your provider will advise on what to use alongside your formula. In general, a gentle cleanser, moisturizer, and daily SPF work well with rosacea treatments.
Oxymetazoline HCl is the active in Rhofade, and Ivermectin is the active in Soolantra. This formula combines both, along with Niacinamide, compounded into a single personalized prescription.
Rosacea is a chronic condition without a permanent cure, but this treatment is designed to help reduce the frequency and severity of flares and the appearance of redness with consistent use.
DoctorDerm treatments combine ingredients into customized formulas that you typically wouldn’t receive as a single prescription in a traditional dermatology office. Our treatments are prepared and delivered directly to your door, giving you a complete skincare experience without the wait times or in-office visits.
$44.50/month. Billed as $89 every 2 months
Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider's prescription. Results may vary.